Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
PQQ (Pyrroloquinoline Quinone Disodium Salt)
20 mg
†
Top Medical Research Studies
9.5
We explored the potential of pyrroloquinoline quinone (PQQ) as a heart protector in rats. In our study, rats experienced conditions simulating heart attacks, with some receiving PQQ beforehand or at the start of recovery.
We found that PQQ significantly reduced heart damage and improved heart function, even showing a dose relationship. Importantly, it also cut down on harmful compounds in heart tissue without causing negative side effects. Overall, PQQ seems promising as a treatment for heart issues.
We found that PQQ significantly reduced heart damage and improved heart function, even showing a dose relationship. Importantly, it also cut down on harmful compounds in heart tissue without causing negative side effects. Overall, PQQ seems promising as a treatment for heart issues.
Read More
8
We explored how Pyrroloquinoline quinone (PQQ) could aid in treating diabetic cardiomyopathy (DCM), a heart condition related to diabetes. Using a select group of mice and human heart cells, we observed that PQQ significantly improved heart health and reduced inflammation through its mechanisms.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
Read More
8
We observed that pyrroloquinoline quinone (PQQ) shows promising protective effects on heart tissue during oxygen reintroduction, an essential process after ischemic events. In our in vitro study, PQQ acts as a substrate for flavin reductase, which helps reduce harmful ferryl myoglobin radicals.
When tested on isolated rabbit hearts, low doses of PQQ effectively shielded the heart from oxidative damage linked to re-oxygenation. The protective mechanism is likely due to PQQ's ability to lower reactive oxygen species, indicating its potential as a therapeutic agent in heart disease.
When tested on isolated rabbit hearts, low doses of PQQ effectively shielded the heart from oxidative damage linked to re-oxygenation. The protective mechanism is likely due to PQQ's ability to lower reactive oxygen species, indicating its potential as a therapeutic agent in heart disease.
Read More
Most Useful Reviews
9
Excellent for heart
2 people found this helpful
Excellent! This product significantly supports the heart and blood vessels.
Read More
7.5
Enhances cellular energy
14 people found this helpful
Continuing with this product is beneficial. It supports cellular energy production, mitochondrial creation, and enhances brain function and memory. Taken over three months, I expect it to improve overall health, including immune cell efficiency, thereby aiding in self-healing, which is crucial for treating heart disease and other ailments.
Read More
6
Supports heart health
3 people found this helpful
It is an important antioxidant that promotes the formation of new mitochondria and supports heart health and cognitive function. It aids mitochondrial biogenesis.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
- All Researches
9.5
We explored the potential of pyrroloquinoline quinone (PQQ) as a heart protector in rats. In our study, rats experienced conditions simulating heart attacks, with some receiving PQQ beforehand or at the start of recovery.
We found that PQQ significantly reduced heart damage and improved heart function, even showing a dose relationship. Importantly, it also cut down on harmful compounds in heart tissue without causing negative side effects. Overall, PQQ seems promising as a treatment for heart issues.
We found that PQQ significantly reduced heart damage and improved heart function, even showing a dose relationship. Importantly, it also cut down on harmful compounds in heart tissue without causing negative side effects. Overall, PQQ seems promising as a treatment for heart issues.
Read More
9
We investigated the effects of low-dose pyrroloquinoline quinone (PQQ) on heart damage during ischemia. In a rat model, PQQ was compared with metoprolol, a well-known heart medication. Both treatments were administered during reperfusion after a period of heart blockage.
The results highlighted that both PQQ and metoprolol reduced heart damage size and improved heart function, especially when combined. However, PQQ showed stronger protection for the heart's mitochondria compared to metoprolol and was the only treatment to decrease harmful lipid peroxidation. Overall, PQQ seems to be very promising for heart health.
The results highlighted that both PQQ and metoprolol reduced heart damage size and improved heart function, especially when combined. However, PQQ showed stronger protection for the heart's mitochondria compared to metoprolol and was the only treatment to decrease harmful lipid peroxidation. Overall, PQQ seems to be very promising for heart health.
Read More
8
We explored how Pyrroloquinoline quinone (PQQ) could aid in treating diabetic cardiomyopathy (DCM), a heart condition related to diabetes. Using a select group of mice and human heart cells, we observed that PQQ significantly improved heart health and reduced inflammation through its mechanisms.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
Read More
8
We explored how pyrroloquinoline quinone (PQQ), a natural antioxidant, could potentially help with cardiac hypertrophy caused by isoproterenol hydrochloride. Using AC16 cells, a model for myocardial injury, we found that PQQ notably reduced markers associated with heart muscle thickening.
Additionally, it seemed to inhibit a specific inflammatory pathway (NF‑κB), which is linked to heart disease progression. These findings suggest that PQQ could be an effective treatment to reverse cardiac hypertrophy, making it a promising candidate for future research in heart health.
Additionally, it seemed to inhibit a specific inflammatory pathway (NF‑κB), which is linked to heart disease progression. These findings suggest that PQQ could be an effective treatment to reverse cardiac hypertrophy, making it a promising candidate for future research in heart health.
Read More
8
We observed that pyrroloquinoline quinone (PQQ) shows promising protective effects on heart tissue during oxygen reintroduction, an essential process after ischemic events. In our in vitro study, PQQ acts as a substrate for flavin reductase, which helps reduce harmful ferryl myoglobin radicals.
When tested on isolated rabbit hearts, low doses of PQQ effectively shielded the heart from oxidative damage linked to re-oxygenation. The protective mechanism is likely due to PQQ's ability to lower reactive oxygen species, indicating its potential as a therapeutic agent in heart disease.
When tested on isolated rabbit hearts, low doses of PQQ effectively shielded the heart from oxidative damage linked to re-oxygenation. The protective mechanism is likely due to PQQ's ability to lower reactive oxygen species, indicating its potential as a therapeutic agent in heart disease.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent for heart
2 people found this helpful
Excellent! This product significantly supports the heart and blood vessels.
Read More
7.5
Enhances cellular energy
14 people found this helpful
Continuing with this product is beneficial. It supports cellular energy production, mitochondrial creation, and enhances brain function and memory. Taken over three months, I expect it to improve overall health, including immune cell efficiency, thereby aiding in self-healing, which is crucial for treating heart disease and other ailments.
Read More
6
Supports heart health
3 people found this helpful
It is an important antioxidant that promotes the formation of new mitochondria and supports heart health and cognitive function. It aids mitochondrial biogenesis.
Read More
7.5
Improves quality of life
1 people found this helpful
PQQ aids in forming new mitochondria, essential for producing healthy cells. With just one easy-to-swallow capsule daily, I’ve noticed significant improvements in my quality of life, increased energy, and reduced lethargy. It is effective in supporting heart health and cognitive functions.
Read More
7.5
Memory improvement
1 people found this helpful
My husband takes PQQ for his heart health and memory. After a year of use, his memory has improved remarkably, now surpassing mine.
Read More
Frequently Asked Questions
7.5
Improves well-being
1 people found this helpful
After three months of taking PQQ, I have noticed significant improvements in my heart and nerves. I feel fitter and healthier overall.
7.5
Enhances cellular energy
14 people found this helpful
Continuing with this product is beneficial. It supports cellular energy production, mitochondrial creation, and enhances brain function and memory. Taken over three months, I expect it to improve overall health, including immune cell efficiency, thereby aiding in self-healing, which is crucial for treating heart disease and other ailments.
7.5
Memory improvement
1 people found this helpful
My husband takes PQQ for his heart health and memory. After a year of use, his memory has improved remarkably, now surpassing mine.
7.5
Improves quality of life
1 people found this helpful
PQQ aids in forming new mitochondria, essential for producing healthy cells. With just one easy-to-swallow capsule daily, I’ve noticed significant improvements in my quality of life, increased energy, and reduced lethargy. It is effective in supporting heart health and cognitive functions.
9
Essential supplement
This supplement is vital for me. It has a positive effect on both heart and brain health, enhancing my well-being.
9
Excellent for heart
2 people found this helpful
Excellent! This product significantly supports the heart and blood vessels.
9
Supports cognitive function
A wonderful supplement when taken in the right dosage. It significantly supports mitochondrial function, heart health, and cognitive function, though it has unfortunately increased in price recently.
8
We explored how Pyrroloquinoline quinone (PQQ) could aid in treating diabetic cardiomyopathy (DCM), a heart condition related to diabetes. Using a select group of mice and human heart cells, we observed that PQQ significantly improved heart health and reduced inflammation through its mechanisms.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
Specifically, PQQ inhibited harmful cell processes that contribute to DCM, suggesting that this natural nutrient could be a promising dietary supplement for managing this condition. Overall, our findings point to PQQ's potential as an effective treatment option in heart disease linked to diabetes.
8
We explored how pyrroloquinoline quinone (PQQ), a natural antioxidant, could potentially help with cardiac hypertrophy caused by isoproterenol hydrochloride. Using AC16 cells, a model for myocardial injury, we found that PQQ notably reduced markers associated with heart muscle thickening.
Additionally, it seemed to inhibit a specific inflammatory pathway (NF‑κB), which is linked to heart disease progression. These findings suggest that PQQ could be an effective treatment to reverse cardiac hypertrophy, making it a promising candidate for future research in heart health.
Additionally, it seemed to inhibit a specific inflammatory pathway (NF‑κB), which is linked to heart disease progression. These findings suggest that PQQ could be an effective treatment to reverse cardiac hypertrophy, making it a promising candidate for future research in heart health.
9
We investigated the effects of low-dose pyrroloquinoline quinone (PQQ) on heart damage during ischemia. In a rat model, PQQ was compared with metoprolol, a well-known heart medication. Both treatments were administered during reperfusion after a period of heart blockage.
The results highlighted that both PQQ and metoprolol reduced heart damage size and improved heart function, especially when combined. However, PQQ showed stronger protection for the heart's mitochondria compared to metoprolol and was the only treatment to decrease harmful lipid peroxidation. Overall, PQQ seems to be very promising for heart health.
The results highlighted that both PQQ and metoprolol reduced heart damage size and improved heart function, especially when combined. However, PQQ showed stronger protection for the heart's mitochondria compared to metoprolol and was the only treatment to decrease harmful lipid peroxidation. Overall, PQQ seems to be very promising for heart health.
References
- Qu XF, Zhai BZ, Hu WL, Lou MH, Chen YH, et al. Pyrroloquinoline quinone ameliorates diabetic cardiomyopathy by inhibiting the pyroptosis signaling pathway in C57BL/6 mice and AC16 cells. Eur J Nutr. 2022;61:1823. 10.1007/s00394-021-02768-w
- Wen J, Shen J, Zhou Y, Zhao X, Dai Z, et al. Pyrroloquinoline quinone attenuates isoproterenol hydrochloride‑induced cardiac hypertrophy in AC16 cells by inhibiting the NF‑κB signaling pathway. Int J Mol Med. 2020;45:873. 10.3892/ijmm.2020.4463
- Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, et al. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One. 2011;6:e21779. 10.1371/journal.pone.0021779
- Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006;11:119.
- Zhu BQ, Zhou HZ, Teerlink JR, Karliner JS. Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. Cardiovasc Drugs Ther. 2004;18:421.
- Xu F, Mack CP, Quandt KS, Shlafer M, Massey V, et al. Pyrroloquinoline quinone acts with flavin reductase to reduce ferryl myoglobin in vitro and protects isolated heart from re-oxygenation injury. Biochem Biophys Res Commun. 1993;193:434.
